Team
The Raeber Lab is part of the Department of Immunoloy at the University of Zurich and University Hospital Zurich. We share state-of-the-art research laboratories and closely collaborate with the Boyman Lab.
Miro Raeber, MD, PhD
Group Leader
Dominic Caspar
PhD Student
Robert Maka
PhD Student
Evgenios Kladis
PhD Student
Alina Martin
Research Associate
Alissa Krek
MD Student
Roberto Colli
MD Student
Boya Zhang
Master Student
Lara Bader
Master Student
Research
Tissue-resident regulatory T cells
Regulatory T cells are crucial for maintaining peripheral tolerance; however, their diverse functional properties in human tissues remain incompletely understood. Characterizing these tissue-resident regulatory T cells in both healthy and autoimmune contexts will provide novel mechanistic insights.
Systemic lupus erythematosus
Systemic lupus erythematosus is an autoimmune disease that affects various organ systems. A better understanding of its underlying pathomechanism will facilitate disease stratification according to inflammatory signatures and the development of novel treatment approaches.
Interleukin-2 for the treatment of autoimmune diseases
Due to its stimulatory effects on regulatory T cells, interleukin-2 (IL-2) has the potential to treat autoimmune diseases. In an investigator-initiated clinical trial, we tested IL-2 in patients with systemic lupus erythematosus, revealing different IL-2-driven regulatory T cell programs.
Publications
Interleukin-2 immunotherapy reveals human regulatory T cell subsets with distinct functional and tissue-homing characteristics
Persistent complement dysregulation with signs of thromboinflammation in active Long Covid
Human memory B cells show plasticity and adopt multiple fates upon recall response to SARS-CoV-2
Zurbuchen Y, Michler J, Taeschler P, Adamo S, Cervia C, Raeber ME, Acar IE, Nilsson J, Warnatz K, Soyka MB, Moor AE, Boyman O
A systematic review of interleukin-2-based immunotherapies in clinical trials for cancer and autoimmune diseases
Interleukin-2-based therapies in cancer
Immunoglobulin signature predicts risk of post-acute COVID-19 syndrome
Cervia C, Zurbuchen Y, Taeschler P, Ballouz T, Menges D, Hasler S, Adamo S, Raeber ME, Bächli E, Rudiger A, Stüssi-Helbling M, Huber LC, Nilsson J, Held U, Puhan MA, Boyman O
Signature of long-lived memory CD8+ T cells in acute SARS-CoV-2 infection
Adamo S, Michler J, Zurbuchen Y, Cervia C, Taeschler P, Raeber ME, Baghai Sain S, Nilsson J, Moor AE, Boyman O
Interleukin-2 signals converge in a lymphoid-dendritic cell pathway that promotes anticancer immunity
The transcription factor Rfx7 limits metabolism of NK cells and promotes their maintenance and immunity
Castro W, Chelbi ST, Niogret C, Ramon-Barros C, Welten SPM, Osterheld K, Wang H, Rota G, Morgado L, Vivier E, Raeber ME, Boyman O, Delorenzi M, Barras D, Ho P, Oxenius A, Guarda G
The role of cytokines in T-cell memory in health and disease
Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'
Levin AM, Bates DL, Ring AM, Krieg C, Lin JT, Su L, Moraga I, Raeber ME, Bowman GR, Novick P, Pande VS, Fathman CG, Boyman O, Garcia KC
Contact
Raeber Lab
Center for Human Immunology
University of Zurich
Haeldeliweg 4
CH-8044 Zurich
+41 44 634 28 65
Support
Gottfried und Julia Bangerter-Rhyner Foundation
EMDO Stiftung
Olga Mayenfisch Stiftung
Fritz Rohrer-Fonds